Download Antidepressants: New Pharmacological Strategies by Luz Romero, Josep Ma Casanovas, Ildefons Hervás, Roser PDF

By Luz Romero, Josep Ma Casanovas, Ildefons Hervás, Roser Cortés (auth.), Phil Skolnick (eds.)

ISBN-10: 1617370487

ISBN-13: 9781617370489

In Antidepressants: present developments and destiny instructions, modern investigators distill the dramatic fresh advances in our figuring out of the mechanisms accountable for antidepressant motion. The authoritative members supply suggestions to enhance present treatments grounded on biogenic amine-based thoughts. by way of departing from conventional options, the authors supply possible choices to remedies that regularly paintings too slowly or in no way, and recommend how the numerous contemporary advances in molecular biology and genetics may most sensible be exploited within the layout of optimum new treatments.

Antidepressants: present developments and destiny instructions summarizes novel strategies of antidepressant remedy that try and take advantage of provocative new insights from the laboratory to enhance present, biogenic amine-based cures. Readers will locate the publication a good source in starting the door to the improvement of more recent and more desirable antidepressant therapies.

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1986) A G protein couples serotonin and GABA-B receptors to the same channel in hippocampus. Science 234, 1261-1265. 130. De Vivo, M. and Maayani, S. (1986) Characterization of the 5-hydroxytryptamine 1A receptor-mediated inhibition of forskolin-stimulated adenylate cyclase activity in guineapig and rat hippocampal membranes. Pharmacal. Exp. Ther. 238,248-253. 131. , and Engel, G. (1986) 5-HTIA receptors mediate stimulation of adenylate cyclase in rat hippocampus. Naunyn-Schmiedeberg's Arch. Pharmacol.

1. Milnacipran Milnacipran inhibits the uptake of radiolabeled 5-HT and NA into rat hypothalamic slices with similar potency (14; Table 1), but not that of dopamine into striatal slices. The compounds, H75/12 and H 77177, are taken up into cells by the selective 5-HT and NA transporter systems, respectively, where they displace endogenous monoamines. This massive release of monoamines leads to a hyperthermic reaction in rats. The reduction of this hyperthermic effect can thus be used as an in vivo indicator of the inhibition of the respective monoamine transporter system.

31. Jacobs, B. L. and Azmitia, E. C. (1992) Structure and function of the brain serotonin system. Physiol. Rev. 72, 165-229. 32. , and Hamon, M. (1984) Autoradiographic evidence for the heterogeneity of 5-htl sites in the rat brain. Brain Res. 291, 159-163. 33. , and Palacios, 1. M. (1986) Serotonin receptors in the human brain. I. Characterization and autoradiographic localization of 5-HTIA recognition sites. Apparent absence of 5-HTlB recognition sites. Brain Res. 376, 85-96. 34. , and Palacios, 1.

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