By Jill P. G. Urban, Robert J. Wilkins (auth.), Seisuke Tanaka M.D., Chiaki Hamanishi M.D. (eds.)
Basic learn on osteoarthritis has been performed customarily from the his tological and biochemical facets of the degenerating chondrocytes, collagen fibers, and matrix proteoglycans. Undue mechanical tension has been proven to be the central think about the initiation of osteoarthritis. even supposing the precise approach in which mechanical rigidity ends up in the complete destruction of cartilage tissue is still doubtful, a number of new examine tools have enabled us to realize a deeper knowing of the method of degeneration. In October 1997, we geared up a world symposium titled "Ad vances in Osteoarthritis" in Kobe, with the most issues being up-to-date re seek, analysis, and remedy of osteoarthritis. The lawsuits of the symposium are awarded right here in 5 sections: (1) Mechanical rigidity and reactions of chondrocytes, akin to intracellular ion alterations, adjustments within the cytoskeleton, intracellular messenger structures, free up of gasoline mediators, and adjustments in electromechanical houses of cartilage; (2) sensible prognosis of osteoarthritis via MR imaging, and utilizing calpain and collagenase III as new cartilage markers; (3) remedy with a promising uncomplicated washout strategy and IL-1RA and MMP antagonists; (4) Cartilage fix by way of new grafting tech niques; and (5) difficulties following overall joint substitute. We basically desire that the complex wisdom supplied during this quantity of lawsuits should be worthwhile to our readers.
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Extra resources for Advances in Osteoarthritis
1. Electrokinetic transduction and effects of electrolyte pH and ionic strength. J Biomech 20:615-627 50. O'Connor P, Orford R, Gardner DL (1988) Differential response to compressive loads of zones of canine hyaline articular cartilage: micromechanical, light and electron microscopic studies. Ann Rheum Dis 47:414-420 51. Jannasch HW, Marquis RE, Zimmerman AM (1987) Current perspectives in high pressure biology. Academic Press, London 52. Urban JPG, Hall AC, Gehl KA (1993) Regulation of matrix synthesis rates by the ionic environment of articular chondrocytes.
Olumoff and E. Vuorio (aggrecan), Dr. L. Fisher (biglycan), and Dr. T. Krusius (decorin and versican) Continuous 30-MPa hydrostatic pressure caused a retarded mobility of aggrecans in agarose gel electrophoresis . This slowing was probably caused by the high magnitude of the pressure, and not by the static mode of the loading, because a 5-MPa continuous pressure did not have a similar effect. A change into a higher molecular weight aggrecan was in line with the finding that in Sephacryl S-lOOO gel chromatography the peak of the monomeric large PGs shifted into a smaller Kav value.
Ann Rheum Dis 52:192198 49. Frank EH, Grodzinsky AJ (1987) Cartilage electromechanics. 1. Electrokinetic transduction and effects of electrolyte pH and ionic strength. J Biomech 20:615-627 50. O'Connor P, Orford R, Gardner DL (1988) Differential response to compressive loads of zones of canine hyaline articular cartilage: micromechanical, light and electron microscopic studies. Ann Rheum Dis 47:414-420 51. Jannasch HW, Marquis RE, Zimmerman AM (1987) Current perspectives in high pressure biology.