By Isaac Asimov
From using metals through prehistoric guy to the alchemical experiments of medieval and renaissance guy to the complicated chemical abilities of latest guy, Asimov strains the improvement of this construction block of our technological international.
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Mol. Genet. Metab. 2011;104 Suppl:S31-9. MacDonald A, Rocha JC, van Rijn M, Feillet F. Nutrition in phenylketonuria. Mol. Genet. Metab. 2011;104 Suppl:S10-8. Aldámiz-Echevarría L, Bueno MA, Couce ML, Lage S, Dalmau J, Vitoria I, Andrade F, Blasco J, Alcalde C, Gil D, García MC, GonzálezLamuño D, Ruiz M, Peña-Quintana L, Ruiz MA, González D, SánchezValverde F. Anthropometric characteristics and nutrition in a cohort of PAH-deficient patients. Clin. Nutr. 2014 Aug;33(4):702-17. Giovannini M, Verduci E, Salvatici E, Paci S, Riva E.
This approach, which consists of a marked reduction in Phe intake, has shown to prevent severe neurological impairment which was observed in untreated patients. However, while several reports indicated that an excessive reduction in Phe intake resulted in poor developmental outcomes in patients with PKU; others have not found evidence of the PKU diet negatively affecting physical development. Considering the importance of attaining optimal growth in patients with PKU, we conducted this retrospective longitudinal study on the developmental outcomes in a Spanish cohort of PAH-deficient patients (PKU and mild-HPA) who were exclusively treated with protein-restricted diets (Study 1).